Cross talk between Wnt/{beta}-catenin and Irf8 in leukemia progression and drug resistance
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Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics and a BCR-ABL model of CML, we observed cross talk between Wnt/β-catenin signaling and the interferon-regulatory factor 8 (Irf8). In normal hematopoiesis, activation of β-catenin results in up-regulation of Irf8, which in turn limits oncogenic ...
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تاریخ انتشار 2017